It is a generic medicine presented as a powder for oral solution, on one-dose sachets for oral administration. Glucosamina Vartiran 1500 mg Powder for oral solution has glucosamine as an active substance. Each satchel has a dose of 1500 mg of glucosamine.

Glucosamina Vartiran is used for the treatment of osteoarthrosis, that is, for the pain and limitation of the function.
Arthrosis is characterized by a degenerative process of the joint cartilage in which it is progressively destroyed. Glucosamina Vartiran contains glucosamine as an active substance, a cartilage constituent necessary for its regeneration, which may stimulate the cells that form the cartilage, contributing to the delay or stop of the degenerative process. (Pharmotherapeutical Group: 9.4 Medicines for the treatment of arthrosis).

DO NOT TAKE GLUCOSAMINA VARTIRAN
• If you’re allergic (hyper sensibility) to the active substance or any of the other ingredients of Glucosamina Vartiran.
• If you’re allergic (hyper sensibility) to seafood, as glucosamine is obtain through seafood.
• Its safety and efficiency have yet to be established on children and adolescents under 18 years old, reason why the administration on these patients should be avoided.

WARNINGS AND PRECAUTIONS
Talk to your doctor, pharmacist or nurse before taking Glucosamina Vartiran.
The glucose intolerant patients must be monitored, and it is necessary to monitor the glycemic values, specially at the beginning of the treatment.
No damaging effects are described on the elderly or on patients with kidney or liver diseases. Nevertheless, the administration to patients with severe kidney or liver disease should be carried out under medical supervision.
Glucosamine is a natural constituent of the organism; therefore it is well tolerated. No further precautions, apart from the above-mentioned, are necessary.
In the case of doubt, talk to your doctor or pharmacist.

OTHER MEDICINES AND GLUCOSAMINA VARTIRAN
Glucosamine may stimulate the gastrointestinal absorption of tetracyclines and may reduce the absorption of penicillin or chloramphenicol, when simultaneously administered orally.
There are no impediments for the concomitant administration with pain-killers or steroidal or nonsteroidal anti-inflammatories. On the contrary, glucosamine may be used as an adjuvant as it develops a cyclooxygenase independent anti-inflammatory therapy and, mainly, it may prevent the joint damages caused by these medicines which, due to its action mechanism, lead to an enzyme block of the proteoglycan synthesis.
Patients who are being treated with anticoagulants (warfarin and acenocoumarol) should be monitored at the beginning and end of the treatment with glucosamine.

PREGNANCY AND BREAST-FEEDING
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
As a precaution, the administration of medicines during your pregnancy should only be carried out when necessary and under medical supervision, mainly on the first three months.
As a precaution, the administration of medicines while breast-feeding should only be carried out when necessary and under medical supervision.

DRIVING AND USING MACHINES
If you are taking Glucosamina Vartiran, there is no inconvenient on driving and using machines as this medicine doesn’t affect your reflexes. Nevertheless, special care is recommended if the development of headaches, drowsiness or visual disturbances is predicted.

GLUCOSAMINA VARTIRAN CONTAINS SODIUM
This medicine contains 384.0 mg of sodium chloride per dose, which corresponds to 151.13 mg of sodium. This information should be considered on patients with a controlled sodium intake.

GLUCOSAMINA VARTIRAN CONTAINS SORBITOL
If you have been informed by your doctor that you are intolerant to certain sugars, contact them before taking this medicine.

GLUCOSAMINA VARTIRAN CONTAINS ASPARTAME
It contains a source of phenylalanine. It may be damaging to patients with phenylketonuria.

Always take this medicine exactly as described in this leaflet or accordingly to your doctor or pharmacist’s indications. Talk to your doctor or pharmacist if you have any doubts.

You should take the content of a sachet (dissolved on a glass of water), once a day, preferably at mealtime.

IF YOU TAKE MORE GLUCOSAMINA VARTIRAN THAN YOU SHOULD
No cases of accidental or intentional overdose were observed. Based on the acute and chronic toxicity data on the animal, no toxic symptoms should be expected, even after high overdoses. Nevertheless, if any overdose episode shall occur, a symptomatic treatment should be carried out, that is, act in order to restore the hydroelectricity balance.

IF YOU FORGET TO TAKE GLUCOSAMINA VARTIRAN
Never take a double dose to compensate a dose you missed.
Continue the treatment normally.

If you have any doubts on the use of this medicine, talk to your doctor or pharmacist.

Like all medicines, this medicine may cause side effects, although not everybody gets them.
Generally, Glucosamina Vartiran is well tolerated.
The most frequent undesirable effects caused by Glucosamina Vartiran are light and transitory and the most common are of a gastrointestinal nature (gastric pain and discomfort, bloating, constipation and diarrhea).

The following list mentions the possible undesirable effects, according to its frequency:

Frequent:
• Gastric pain and discomfort
• Bloating
• Constipation
• Diarrhea
• Nausea
• Headache
• Drowsiness

Infrequent:
• Pruritus skin rash
• Erythema

Rare:
• Allergic reactions
• Visual disturbances
• Hair loss

REPORTING OF SIDE EFFECTS
If you get any side effects, including possible side effects not included on this leaflet, talk to your doctor, pharmacist or nurse. You can also report side effects directly to the INFARMED, I.P., via the contacts below. By reporting side effects, you are helping to provide more data on the safety of this medicine.
INFARMED, I.P.
Direção de Gestão do Risco de Medicamentos
Parque da Saúde de Lisboa, Av. Brasil 53
1749-004 Lisboa
Tel: +351 21 798 73 73
Medicine Hotline: 800 222 444 (free of charge)
Fax: +351 21 798 73 97
Website: http://www.infarmed.pt/web/infarmed/submissaoram
Email: farmacovigilancia@infarmed.pt

WHAT GLUCOSAMINA VARTIRAN CONTAINS
The active substance is sodium chloride of glucosamine sulfate. Each sachet has a dose of 1500 mg of glucosamine.
The other components (excipients) are: aspartame, sorbitol, anhydrous citric acid and macrogol 4000.

WHAT GLUCOSAMINA VARTIRAN LOOKS LIKE AND THE CONTENTS OF THE PACK
Glucosamina Vartiran 1500 mg Powder for oral solution is available on packages of 20, 30, 60 and 90 sachets. It is possible that not all presentations are sold.

MARKETING AUTHORIZATION HOLDER
toLife - Produtos Farmacêuticos, S.A.
Av. do Forte, 3, Edif. Suécia IV, Piso 0
2794-093 Carnaxide
Portugal

MANUFACTURER
Generis Farmacêutica S.A.
Rua João de Deus, nº 19, Venda Nova
2700-487 Amadora
Portugal

Detailed and updated information on this medicine is available through the scan of the 2D code included on the package with a smartphone. The same information is also available on the following URL: https://www.tolifeotc.com/vartiran.

This leaflet was last revised on July 2019.